With the present date set ten years after the events of The Conspiracy, Travel in Time features crimes all around the world and all across time.
Travel in Time features a stylized world map divided into seven time periods, across which are located a total of thirty-one cases:
Ancient Times is the first time period investigated in Travel in Time. Ranging from 47 BCE to 37 BCE, it focuses on T.I.M.E. working to rebuild history after a time disturbance caused by a rogue time traveler, creating ripple effects that disrupted history. It also focuses on the conquests of the Roman Empire and the time machine malfunctioning after a runaway slave sneaks onboard.
The 1960s is the second time period investigated in Travel in Time. Taking place in 1969, it focuses on finding a way to get back to the present day after an organization sabotaged the team's time machine to permanently strand them. It also takes place amidst the Cold War, a period of geopolitical tension between the United States and the Soviet Union, who raced over ideological hegemony over the world, the conquer of outer space and the development of nuclear weapons.
Renaissance is the third time period investigated in Travel in Time. Taking place in 1515, it focuses on finding Leonardo da Vinci regarding his formula on time travel in order for the team's time machine to be repaired to go back to 2029. It also focuses on getting Penelope's budding relationship with a dashing musketeer.
Altered Present is the fourth time period investigated in Travel in Time. Taking place in an altered version of 2029, it focuses on the team discovering what caused an alternate time stream to be created wherein time travel and T.I.M.E. did not exist and where New York City was replaced with New Cairo, a city ruled by the tyrannical Ptolemy Dynasty.
Age of Sail is the fifth time period investigated in Travel in Time. Taking place in 1719, it focuses on getting to a port and plantation auction in Tortuga in order to undo the time machine saboteur's securing of shipping and trade routes, which proved crucial to the Ptolemy Dynasty's rise in power.
Medieval Asia is the sixth time period investigated in Travel in Time. Taking place in 1235, it focuses on preventing Ammon Bast's last-ditch efforts to alter history by providing the expansionist Mongol Empire with 18th-century weapons and piggybacking on the consequent destruction of the Chinese Empire to help the Ptolemy Dynasty rise to power.
The End is the seventh and final time period investigated in Travel in Time. Taking place in 47 BCE, it focuses on the team returning to Ancient Egypt and attempting to restore the original timeline by preventing Nefertiti and Ammon Bast from sabotaging the team's time machine in the first place.
Case #31 is situated in this time period.